The small and simple benzothiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess interesting biological activities, such as antitumor, antimicrobial, anti diabetic, anthelmintic, antileishmanial, anticonvulsant and anti-inflammatory. The present review focuses on the benzothiazoles derivatives with potential anti microbial activity that are now in development. In recent year heterocyclic compounds analogues and derivatives have attracted strong interest due to their useful biological and pharmacological properties. Literature revealed that Benzothiazole derivatives may serve as an important model of potent anti microbial agents. When one biological active molecule is linked to another, resultant molecule generally has increased potency. Based on the literature review, the biological profiles of these new generations of benzothiazoles derivatives represent much progress with regards to older compounds.
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